Walking Training Improves Systemic and Local Pathophysiological Processes in Intermittent Claudication

نویسندگان

چکیده

ObjectiveThis study examined the impact of submaximal walking training (WT) on local and systemic nitric oxide (NO) bioavailability, inflammation, oxidative stress in patients with intermittent claudication (IC).MethodsThe employed a randomised, controlled, parallel group design was performed single centre. Thirty-two men IC were randomly allocated to two groups: WT (n = 16, sessions/week, 15 cycles minutes at an intensity corresponding heart rate obtained pain threshold interspersed by upright rest) control (CO, n 30 stretching). NO bioavailability (blood muscle synthase [eNOS]), redox homeostasis (catalase [CAT], superoxide dismutase [SOD], lipid peroxidation [LPO] measured blood muscle), inflammation (interleukin-6 [IL-6], C-reactive protein [CRP], tumour necrosis factor ? [TNF-?], intercellular adhesion molecules [ICAM], vascular [VCAM] muscle) assessed baseline after 12 weeks.ResultsWT statistically significantly increased NO, eNOS, SOD CAT, abolished increase circulating LPO observed CO group. decreased CRP, ICAM, VCAM IL-6 CRP eliminated TNF-? TNF-?, ICAM group.ConclusionWT improved IC. The proposed protocol provides physiological adaptations that may contribute cardiovascular health these patients. This (IC). weeks.

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ژورنال

عنوان ژورنال: European Journal of Vascular and Endovascular Surgery

سال: 2021

ISSN: ['1078-5884', '1532-2165']

DOI: https://doi.org/10.1016/j.ejvs.2021.02.022